The influence of differing inspired oxygen concentrations on platelet function in a model of lower limb ischaemic reperfusion injury

Not Applicable

• Conditions: Ischaemic reperfusion injuries; Blood - Clotting disorders; Anaesthesiology - Anaesthetics; Anaesthesiology - Other anaesthesiology

• Registration Number: ACTRN12610000139077
• Lead Sponsor: Royal Perth Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-02-10
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

1. Adult patients undergoing lower limb surgery that requires the use of a tourniquet for more than 45 minutes
2. American Society of Anaesthesiology (ASA) grade 1 or 2

Exclusion Criteria

1. Patients taking any antiplatelet medication 2. Confirmed coagulation disorder (pathological or drug induced) 3. Platelet count less then 80 x 109/l 4. Blood urea greater than 8.0 mmol/L 5. Systemic infection 6. Confirmed systemic Inflammatory diseases 7. Documented pregnancy 8. Documented malignancy 9. Trauma other than the ipsilateral lower limb 10. Multiple tourniquet episodes 11. Likely intraoperative O2 requirement > 30%

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in platelet activation as assessed by flow cytometry (degree of change unknown)[pre induction, 10 mins pre tourniquet deflation, immediately pre tourniquet deflation, 5 mins post tourniquet, 30 mins and 24 hours post tourniquet deflation]

Secondary Outcome Measures

Name	Time	Method
Change in platelet activation as assessed by thromboelastography (degree of change unknown)[pre induction, 10 mins pre tourniquet deflation, immediately pre tourniquet deflation, 5 mins post tourniquet, 30 mins and 24 hours post tourniquet deflation]