Validation of COVILUS Score in Patients Suspected of COVID-19 Infection in the Emergency Room

Completed

• Conditions: Covid19; Lung Ultrasound; Respiratory Complication

• Registration Number: NCT04666064
• Lead Sponsor: Centre Hospitalier Universitaire, Amiens

Brief Summary

Covid-19 (English acronym meaning coronavirus disease 2019) is an emerging infectious disease caused by a strain of coronavirus called SARS-CoV-2. The current pandemic has resulted in a significant number of admissions in the emergency room (ER) due to suspicion of COVID-19 infection. Use of lung ultrasound is standard practice to diagnose acute respiratory failure in ER. Recently, typical lung ultrasonographic characteristics of COVID-19 disease has been described. The investigators demonstrated that the association of 4 signs in pulmonary ultrasound associated with a clinical sign (COVILUS score) could predict the occurrence of a positive RT-PCR in patients suspected of COVID-19 infection admitted to the emergency room. The investigators are going to conduct a new study to validate this COVILUS score in this type of patient. The main objective will be to validate the diagnostic performance of lung ultrasound in patients admitted to the emergency room with suspected COVID19 infection.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-12-10
• Study First Submitted: 2020-12-11
• Study First Submitted QC: 2020-12-11
• Study First Posted: 2020-12-14
• Primary Completion: 2021-04-28
• Study Completion: 2021-04-28
• Status Verified: 2021-07
• Last Update Submitted: 2021-07-20
• Last Update Posted: 2021-07-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• patients admitted to ER for suspicion of COVID-19 infection who has a SARS-CoV-2 RT-PCR test and for whom the emergency doctor decide to perform a lung ultrasound as part of the BLUE protocol
• Age> 18 years old

Exclusion Criteria

• patients < 18 years of age
• patients under guardianship or curators
• pregnancy
• poor echogenicity due to the presence of an acoustic barrier (pneumothorax, subcutaneous emphysema, etc.)
• patients with a suspected or proven acute lung disease (pneumonitis, acute respiratory distress syndrome (ARDS))
• patients with chronic interstitial lung disease
• patients who will refuse to give their consent.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
concordance between Covid19 RT-PCR results and lung ultrasound results	one week

Trial Locations

Locations (1)

BAR; 🇫🇷 Amiens, France