Prospective Evaluation of Diagnosis of Vitamin D Deficiency in Critical Care

• Conditions: Vitamin D deficiency; E55

• Registration Number: DRKS00009216
• Lead Sponsor: Klin. Abt. f. Endokrinologie und DiabetologieUniv. Klin. f. Innere MedizinMedizinische Universität Graz

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2016-03-15
• Study Completion: 2018-03-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 76

Inclusion Criteria

cardiovascular or transplant surgery patients who have a high anticipated risk of staying in the ICU >48 hours postoperatively

Exclusion Criteria

inclusion in interventional trial, failure to obtain patient consent

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in vitamin D levels between the preoperative measurement (induction of anaesthesia) and day two of intensive care stay

Secondary Outcome Measures

Name	Time	Method
Changes in vitamin D status between the preoperative measurement (induction of anaesthesia) and the other time points in the study (intraoperative, postoperative ICU stay day 1, 3 - 7).<br>Vitamin D levels at the defined time points (preoperative, intraoperative, postoperative ICU stay day 1 - 7).<br>Conformance of the ECLIA assay and LC-MS as well as quantification of the C3 epimer in a subset of frozen samples. <br>Hospital mortality adjusted for vitamin D status and relevant cofactors (age, gender, race, renal function, markers of inflammation).