A trial to compare pain in patients with chronic pancreatitis undergoing early versus late surgery.

Not Applicable

Conditions: Health Condition 1: K860- Alcohol-induced chronic pancreatitis

Registration Number: CTRI/2023/05/052196

Lead Sponsor: Department of surgical gastroenterology.

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Yet Recruiting

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

Inclusion criteria

Age > 18 years

typical clinical history of chronic pancreatitis

â?ª one or more of the following additional criteria for the diagnosis of CP:

1. Pancreatic calcifications on CT or MRI imaging.

2. Moderate or marked ductal lesions on endoscopic retrograde cholangiopancreatography (ERCP) or magnetic resonance cholangiopancreatography (MRCP) imaging.

3. Marked and persistent exocrine insufficiency (defined as: a. pancreatic steatorrhea clearly relieved by enzyme supplementation, and/or b. fecal elastase levels of <= 200 micro gram/gram)

4. Dilated pancreatic duct: dilated pancreatic duct of >= 5 mm, with or without enlargement of the pancreatic head.

5. Presence of moderate, non-debilitating pain FOR EARLY SURGERY GROUP

6 Presence of debilitating pain not amenable to strong opiods for standard surgery group

Exclusion Criteria

Exclusion criteria

1.History of prolonged need of opioids- weak opioids for CP for a total period of 6 months in the last 2 years.

2.Previous pancreatic surgery

3.Previous endoscopic dilatation or stenting of the pancreatic duct /biliary

4.Autoimmune pancreatitis

5.Stones and strictures exclusively located in the tail of the pancreas

6.Fully impacted stones casting the entire main pancreatic duct (from head to tail) and possibly side branches

7.Suspected or confirmed pancreatic malignancy

8.Life expectancy of < 1 year for any reason

9.Presence of duodenal obstruction necessitating surgery.

10.Presence of a pseudocyst larger than 6 cm necessitating intervention.

11.severe portal hypertension due to occluded portal vein

12.Pregnancy

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To comparison of pain score after early surgery in CP with current Standard management (late surgery).Timepoint: 12 months

Secondary Outcome Measures

Name	Time	Method
To assesses the quality of life, post procedural complications, disease progression, exocrine and endocrine dysfunction during the follow up period.Timepoint: 2 years