A Phase 2 Study of MK-4280A for the Treatment of Selected Solid Tumors
- Conditions
- eoplasm malignantMedDRA version: 21.0Level: LLTClassification code: 10049280Term: Solid tumour Class: 10029104Therapeutic area: Diseases [C] - Neoplasms [C04]
- Registration Number
- CTIS2023-505022-34-00
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 195
Histologically confirmed diagnosis of resectable cutaneous squamous cell carcinoma cSCC as the primary site of malignancy (metastatic skin involvement from another primary cancer or from an unknown primary cancer is not permitted) - Cohort A, Is assigned female sex at birth, at least 18 years of age at the time of providing the informed consent - Cohort B, Has adequately controlled blood pressure without antihypertensive medication - Cohort B, Agrees to follow contraception guidelines if a participant of childbearing potential, Has a life expectancy >3 years per investigator assessment, Has adequate organ function, Has Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1, If positive for hepatitis B, has received antiviral therapy for =4 weeks and undetectable viral load prior to randomization, If positive for hepatitis C, has undetectable viral load at screening, If positive for human immunodeficiency virus (HIV), has well-controlled HIV on a stable highly active antiretroviral therapy, Stage II to Stage IV disease without M1. cSCC tumors arising in the head and neck will be staged according to AJCC Ed. 8 and cSCC tumors arising in non-head and neck locations will be staged according to UICC Ed. 8. - Cohort A, Is systemic treatment naïve. - Cohort A, Archival tumor tissue sample, or newly obtained surgical resection, or biopsy sample of a tumor lesion not previously irradiated has been provided - Cohort A, Is an individual of any sex/gender, at least 18 years of age at the time of providing the informed consent - Cohort A, Histologically confirmed diagnosis of EC that is not dMMR (pMMR) as documented by a local test report. - Cohort B, Documented evidence of stage IVB (per 2009 International Federation of Gynecology and Obstetrics (FIGO) staging), recurrent, or metastatic EC, and are not candidates for curative surgery or radiation - Cohort B, Has radiographic evidence of disease progression after 1 prior systemic, platinum-based chemotherapy regimen for EC in any setting - Cohort B, Measurable disease per Response Evaluation Criteria In Solid Tumors (RECIST 1.1) by investigator (before first dose of study intervention) - Cohort B
Has known hypersensitivity to active substances or their excipients including previous clinically significant hypersensitivity reaction to treatment with other monocloncal antibody (mAb), Has clinically significant cardiovascular disease within 12 months from first dose of study intervention - Cohort B, History of allogeneic tissue/solid organ transplant, Received prior radiotherapy to the index lesion (in-field lesion) - Cohort A, Participants for whom the primary site of cSCC was anogenital area (penis, scrotum, vulva, perianal region) are not eligible - Cohort A, Has had major surgery within 3 weeks prior to first dose of study interventions - Cohort B, Has preexisting =Grade 3 gastrointestinal or non-gastrointestinal fistula - Cohort B, Has urine protein =1 g/24 hours - Cohort B, Has a left ventricle ejection fraction (LVEF) below the institutional (or local laboratory) normal range, as determined by multigated acquisition (MUGA) or echocardiogram (ECHO) - Cohort B, Has radiographic evidence of encasement or invasion of a major blood vessel, or of intratumoral cavitation - Cohort B
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method