Dexamethasone and Analgesic Duration After Supraclavicular Brachial Plexus Blockade

Not Applicable

Completed

• Conditions: Anesthesia
• Interventions: Drug: Dexamethasone; Drug: Mepivicaine

• Registration Number: NCT00802009
• Lead Sponsor: University Health Network, Toronto

Brief Summary

Patients undergoing surgery of the hand often are treated with a nerve block in the shoulder/neck area that provides anesthesia/numbing during surgery. Nerve blocks usually last for a few hours after surgery and provide pain relief for this period. It may be possible to extend the duration of anesthesia by using a steroid, which has anti-inflammtory properties. This study will compare the duration of the nerve block when dexamethasone (steroid) is added to the anesthetic injected around the nerve.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2008-12-02
• Study First Submitted QC: 2008-12-03
• Study First Posted: 2008-12-04
• Study Start: 2009-05
• Primary Completion: 2009-10
• Study Completion: 2009-11
• Status Verified: 2010-01
• Last Update Submitted: 2010-01-22
• Last Update Posted: 2010-01-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 44

Inclusion Criteria

1. Patients having unilateral hand or forearm surgery under Supraclavicular brachial plexus blockade.
2. ASA I-III
3. Age 18-60
4. BMI < 35

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Exclusion Criteria

1. Patients with a known history of hypersensitivity to local anesthetics and dexamethasone.
2. Contra-indication to regional anesthesia/ supraclavicular brachial plexus blockade e.g. bleeding diathesis, coagulopathy.
3. Peripheral neuropathy.
4. Peptic ulcer disease.
5. Diabetes Mellitus.
6. Inability to give informed consent.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
1	Dexamethasone	Dexamethasone 8mg added to routine local anesthetic during brachial plexus blockade.
1	Mepivicaine	Dexamethasone 8mg added to routine local anesthetic during brachial plexus blockade.
2	Mepivicaine	Routine anesthetic solution (30 cc 1.5% mepivicaine) used during brachial plexus blockade.

Primary Outcome Measures

Name	Time	Method
Duration of anesthesia	hourly for first 24 hours; daily until discharge

Secondary Outcome Measures

Name	Time	Method
Requirements for pain medications; complications	up to 3 months

Trial Locations

Locations (1)

Toronto Western Hospital, University Health Network; 🇨🇦 Toronto, Ontario, Canada