Clinical effect and mechanism of Shenan decoction in the treatment of diabetic nephropathy:A Randomized Controlled Clinical trial study Protocol
- Conditions
- Diabetic Nephropathy
Recruitment & Eligibility
- Status
- Pending
- Sex
- Male
- Target Recruitment
- Not specified
1. It also meets the syndrome differentiation criteria of Chinese medicine for thirst dissipating nephropathy (deficiency of both Qi and Yin combined with stasis and toxin), Western medicine diagnostic criteria for type 2 diabetes and diabetic nephropathy (stage IV).
2. Aged 18 to 70 years,Male or Female;
3. Fasting blood glucose was less than 11.0mmol/L and 2h postprandial blood glucose was less than 15mmol/L;HbA1c does not exceed 8.0%;
4. GFR > 60ml/min and 24-hour urinary protein quantification < 5.0g/24h, systolic blood pressure is controlled in 140-90mmHg, diastolic blood pressure is controlled in 90-60mmHg;
5. Patients were informed and voluntarily participated in the experimental study and signed the consent form, showing good compliance.
1. Suffering from mental disorders who are unable to cooperate with treatment and cannot follow the medical advice and receive treatment on time;
2. With recent acute complications and combined infection;
3. Women who are pregnant, lactating or preparing to become pregnant, or who are allergic to the drug used in the test;
4. Have received hemodialysis and kidney transplantation.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Glycosylated hemoglobin; Urinary protein quantification;Scr;FBG(fasting blood-glucose);Glomerular filtration rate;Symptom score;Proteomics;PBG(FBG(fasting blood-glucose));Metabonomics;
- Secondary Outcome Measures
Name Time Method Total cholesterol;LDL;HDL;Triglyceride;