Low Grade Inflammation in Type 1 Diabetes Children
- Conditions
- Type 1 DiabetesInflammation
- Registration Number
- NCT01099956
- Lead Sponsor
- University Hospital, Bordeaux
- Brief Summary
The study propose to measure the inflammation level in type 1 diabetes children with the cytokine analysis compared to non diabetic children of the same sibling and to healthy children.
- Detailed Description
The increase of type 1 diabetes incidence, particularly in young children leads to conduce new diagnostic and therapeutic strategies, notably for associated chronic morbidity.Measurement of chronic inflammation, with modification of the balance between pro-inflammatory cytokines and anti-inflammatory cytokines, could lead to detect patients with high risk to diabetes chronic morbidity.
After parental consent, blood sampling will be carried out by micromethod for cytokine (500 µl) and CRPhs dosages and glycemia (100 µl) and glycated hemoglobin (1 µl). Urine will be collected (50 ml) in the morning for further researches.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 80
Type 1 diabetes children group :
- Children aged 2 to 17 years
- Type 1 diabetes children
Controlled group :
- Children aged 2 to 17 years
- Brother or sister of type 1 diabetes children
- Per os or inhaled corticoid in the previous month of inclusion
- Acute infectious disease in the previous week of inclusion
- Other chronic disease than diabetes type1
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Increase of Interleukine 6 in group DTI versus control group Once at inclusion
- Secondary Outcome Measures
Name Time Method Increase of others cytokines (IL1-beta, l'IL-4, l'IL-10 and TNF alpha) and increase of High sensitivity CRP in group DTI versus control group Once at inclusion
Trial Locations
- Locations (1)
Children Hospital, Endocrinology Unit
🇫🇷Bordeaux, France