Low Grade Inflammation in Type 1 Diabetes Children
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Increase of Interleukine 6 in group DTI versus control group
研究概览
简要总结
The study propose to measure the inflammation level in type 1 diabetes children with the cytokine analysis compared to non diabetic children of the same sibling and to healthy children.
详细描述
The increase of type 1 diabetes incidence, particularly in young children leads to conduce new diagnostic and therapeutic strategies, notably for associated chronic morbidity.Measurement of chronic inflammation, with modification of the balance between pro-inflammatory cytokines and anti-inflammatory cytokines, could lead to detect patients with high risk to diabetes chronic morbidity.
After parental consent, blood sampling will be carried out by micromethod for cytokine (500 µl) and CRPhs dosages and glycemia (100 µl) and glycated hemoglobin (1 µl). Urine will be collected (50 ml) in the morning for further researches.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 2 Years 至 17 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Type 1 diabetes children group :
- •Children aged 2 to 17 years
- •Type 1 diabetes children
- •Controlled group :
- •Children aged 2 to 17 years
- •Brother or sister of type 1 diabetes children
排除标准
- •Per os or inhaled corticoid in the previous month of inclusion
- •Acute infectious disease in the previous week of inclusion
- •Other chronic disease than diabetes type1
结局指标
主要结局
Increase of Interleukine 6 in group DTI versus control group
时间窗: Once at inclusion
次要结局
- Increase of others cytokines (IL1-beta, l'IL-4, l'IL-10 and TNF alpha) and increase of High sensitivity CRP in group DTI versus control group(Once at inclusion)