A Pilot Trial of the Tolerability and Clinical Effectiveness of Letermovir When Used for Secondary Prophylaxis to Prevent Recurrent Cytomegalovirus Disease in Solid Organ Transplant Recipients

Tufts Medical Center1 site in 1 country25 target enrollmentFebruary 2, 2023

ConditionsCytomegalovirus Infections Infection in Solid Organ Transplant Recipients Neutropenia Antiviral Toxicity

InterventionsLetermovir

DrugsLetermovir

Overview

Phase: Phase 4
Intervention: Letermovir
Conditions: Cytomegalovirus Infections
Sponsor: Tufts Medical Center
Enrollment: 25
Locations: 1
Primary Endpoint: Rate of Relapse after prophylaxis
Status: Recruiting
Last Updated: last year

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Sites Similar Trials

Overview

Brief Summary

This is a research study to test the tolerability and clinical effectiveness of the study drug, Letermovir (LET), when used as secondary prophylaxis following treatment of Cytomegalovirus (CMV) infection and disease in a solid organ transplant recipient.

This study is an open label trial in which Letermovir will be prescribed to prevent the recurrence of CMV infection and disease in a solid organ transplant recipient following treatment of CMV infection or disease.

Detailed Description

This study will enroll solid organ transplant recipients who develop cytomegalovirus infection and disease who have been treated. At the time of finishing treatment, if the clinician feels that secondary prophylaxis is indicated, they will be enrolled to receive Letermovir 480 mg orally once a day for 60 days. CMV specific T cell assays will be obtained at the initiation of secondary prophylaxis and at the discontinuation of secondary prophylaxis. Patients will be followed for 4 months following discontinuation of secondary prophylaxis to see if they relapse.

Registry

clinicaltrials.gov

Start Date

February 2, 2023

End Date

December 15, 2025

Last Updated

last year

Study Type

Interventional

Study Design

Single Group

Sex

All

Investigators

Sponsor

Tufts Medical Center

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Adult (\> 18 years old) solid organ transplant recipients (heart, kidney or liver patients) recovering from treated CMV disease in whom the clinician deems that the patient need secondary prophylaxis and in whom written informed consent is obtained.
•Patient able to participate with follow up for 6 months
•Not enrolled in competing clinical trials

Exclusion Criteria

•Patients with creatinine clearance less than 10 ml per min at time of enrollment
•Hypersensitivity to letermovir or has a CMV isolate which is known to be resistant to letermovir based on prior testing
•On CVVH or renal dialysis at the time of enrollment
•Has Child Pugh Class C severe hepatic insufficiency at screening.
•Has both moderate hepatic insufficiency AND moderate to severe renal insufficiency at screening.
•Note: Moderate hepatic insufficiency is defined as Child Pugh Class B (Appendix 8); moderate to severe renal insufficiency is defined as CrCl \<50 mL/min, as calculated by the Cockcroft-Gault equation.
•Has a history of malignancy ≤5 years prior to signing informed consent except for adequately treated basal cell or squamous cell skin cancer or in situ cervical cancer or carcinoma in situ; or is under evaluation for other active or suspected malignancy.
•Is pregnant or expecting to conceive, is breastfeeding, or plans to breastfeed from the time of consent through at least 90 days following cessation of study therapy.
•Is expecting to donate eggs or sperm starting from the time of consent through at least 90 days following cessation of study therapy.
•Has a history or current evidence of any condition, therapy, lab abnormality, or other circumstance that might confound the results of the study, interfere with the participant's participation for the full duration of the study, or put the participant at undue risk, as judged by the investigator, such that it is not in the best interest of the participant to participate in this study.