A pilot study: impaired pulmonary diffusion capacity on exercise in patients with pulmonary arterial hypertension

Mater Hospital0 个研究点目标入组 30 人开始时间: 2024年2月26日最近更新: 2024年3月11日

适应症

试验速览

暂无简介。

•Group 1 PAH:
•1. Patients with diagnosed idiopathic pulmonary artery hypertension (IPAH)/drug-induced pulmonary artery hypertension (DPAH)/heritable pulmonary arterial hypertension (HPAH)/connective tissue disease (CTD) PAH who are stable for the past three months on PH-specific targeted therapy.
•2. Normal spirometry
•3. No evidence of interstitial lung diseases (ILD)/emphysema on CT scan
•4. Never smokers or ex-smokers with less than equal to 10 pack years h/o smoking
•5. Age 18-65 years
•Age-matched controls:
•1. No h/o cardiovascular disease
•2. BMI <25 kg/m²
•3 Never smoker
•4. Normal spirometry
•5. Do not currently meet the recommended physical activity government guidelines of at least 150 minutes of moderate-intensity aerobic activity per week
•6. Age 18-65 years

•1. Unable to provide written consent
•2. Unable to perform the incremental shuttle walk test
•3. Pregnant and breastfeeding mothers
•4. Healthy volunteers with abnormal pulmonary function test (PFT) data
•5. Control group or PAH patients who cannot obtain two reproducible baseline DLCO measurements within three attempts

发起方

Mater Hospital