Abnormal diffusion capacity of the lung on exercise in patients with high blood pressure in the blood channels of the lung also known as pulmonary arterial hypertensio
- Conditions
- Pulmonary hypertensionCirculatory System
- Registration Number
- ISRCTN65855577
- Lead Sponsor
- Mater Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Ongoing
- Sex
- All
- Target Recruitment
- 30
Group 1 PAH:
1. Patients with diagnosed idiopathic pulmonary artery hypertension (IPAH)/drug-induced pulmonary artery hypertension (DPAH)/heritable pulmonary arterial hypertension (HPAH)/connective tissue disease (CTD) PAH who are stable for the past three months on PH-specific targeted therapy.
2. Normal spirometry
3. No evidence of interstitial lung diseases (ILD)/emphysema on CT scan
4. Never smokers or ex-smokers with less than equal to 10 pack years h/o smoking
5. Age 18-65 years
Age-matched controls:
1. No h/o cardiovascular disease
2. BMI <25 kg/m²
3 Never smoker
4. Normal spirometry
5. Do not currently meet the recommended physical activity government guidelines of at least 150 minutes of moderate-intensity aerobic activity per week
6. Age 18-65 years
1. Unable to provide written consent
2. Unable to perform the incremental shuttle walk test
3. Pregnant and breastfeeding mothers
4. Healthy volunteers with abnormal pulmonary function test (PFT) data
5. Control group or PAH patients who cannot obtain two reproducible baseline DLCO measurements within three attempts
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method