The Effect of Propofol Based Total Intravenous Anesthesia on Oxidative Stress and Nitric Oxide in Patients Undergoing Laparoscopic Surgery
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- changes of serum malondialdehyde, Interleukin-1β, interleukin-6, tumor necrotic factor-α, nitric oxide during operation
研究概览
简要总结
Robot assisted laparoscopic radical prostatectomy(Robot-LRP) requires pneumoperitoneum and trendelenburg position which result in oxidative stress and inflammatory response.
Propofol is well known to reduce those responses during anesthesia. Therefore, we try to figure out the efficacy of propofol to reduce oxidative stress, inflammatory response and increase the nitric oxide activity during robot-LRP compared to that of desflurane.
To investigate the oxidative stress, malondialdehyde will be measured. As inflammatory markers, interleukin-1β, interleukin-6, tumor necrosis factor-α will be measured. Nitric oxide will be measured as well.
Secondarily, kidney protection effect of propofol over desflurane will be compared.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •patients undergoing robot-assisted laparoscopic radical prostatectomy under general anesthesia
排除标准
- •chronic renal failure ( estimated glomerular filtration rate <60 mL/min/1.73m2)
- •allergy to propofol, nuts
- •on diuretics, vitamin C or vitamin E within 5 days before surgery
- •Body mass index > 30 kg/m2
- •older than 70 years
- •who cannot read the patient consent form
研究组 & 干预措施
desflurane
use desflurane as a primary anesthetics during anesthesia guided by bispectral index (BIS)
干预措施: Desflurane (Drug)
propofol
propofol infusion with target-controlled infusion(TCI) device guided by BIS
干预措施: propofol (Drug)
结局指标
主要结局
changes of serum malondialdehyde, Interleukin-1β, interleukin-6, tumor necrotic factor-α, nitric oxide during operation
时间窗: 100 min after pneumoperitoneum, 10 min after decompression
次要结局
- kidney function after anesthesia(1 day after operation)