Incidence, Risk Factors, and Risk Model of Acute Kidney Injury After Thoracic Aortic Surgery

Completed

• Conditions: Thoracic Aortic Surgery
• Interventions: Other: Electronic Medical Record (EMR) Review

• Registration Number: NCT01401218
• Lead Sponsor: Samsung Medical Center

Brief Summary

Postoperative acute kidney injury (AKI) is still one of the serious complications of thoracic aortic surgery, with incidence of 8 to 50 percent. Postoperative AKI significantly increases the morbidity and mortality of patients undergoing thoracic aortic surgery. Previous studies for AKI after DHCA reported confounding results due to different criteria of AKI. Therefore, the investigators tried to evaluate the incidence and risk factors of AKI after thoracic aortic surgery according to the diagnostic criteria and staging system of AKI reported from acute kidney injury network. The investigators also tried to develop a risk model with scoring system of AKI and evaluate the performance of the risk model.

Detailed Description

Significant improvement of morbidity and mortality has been achieved during last three decades since developing deep hypothermic circulatory arrest (DHCA). However,postoperative acute kidney injury (AKI) is still one of the serious complications of thoracic aortic surgery, with incidence of 8 to 50 percent. Postoperative AKI significantly increases the morbidity and mortality of patients undergoing thoracic aortic surgery. Previous studies for AKI after DHCA reported confounding results due to different criteria of AKI. Therefore, the investigators tried to evaluate the incidence and risk factors of AKI after thoracic aortic surgery according to the diagnostic criteria and staging system of AKI reported from acute kidney injury network (2007). The investigators also tried to develop a risk model with scoring system of AKI and evaluate the performance of the risk model.

Study Timeline

• Study Start: 2011-07
• Study First Submitted: 2011-07-21
• Study First Submitted QC: 2011-07-22
• Study First Posted: 2011-07-25
• Primary Completion: 2012-09
• Study Completion: 2012-09
• Status Verified: 2013-12
• Last Update Submitted: 2013-12-24
• Last Update Posted: 2013-12-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 799

Inclusion Criteria

• patients who underwent thoracic aortic surgery during 1994 to 2010 period

Exclusion Criteria

• patients who had previous renal failure before aortic surgery

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
thoracic aortic surgery group	Electronic Medical Record (EMR) Review	patients who underwent thoracic aortic surgery

Primary Outcome Measures

Name	Time	Method
presence of Acute kidney injury	1 time, within 48 hours of aortic surgery	diagnosis of AKI if the record of patient meet one of the below criteria; 1. abrupt (within 48 hours) reduction in kidney function currently defined as; 2. absolute increase in serum creatinine of more than or equal to 0.3 mg/dl (≥ 26.4 μmol/l),; 3. a percentage increase in serum creatinine of more than or equal to 50% (1.5-fold from baseline), or; 4. a reduction in urine output (documented oliguria of less than 0.5 ml/kg per hour for more than six hours)

Trial Locations

Locations (1)

Samsung Medical Center; 🇰🇷 Seoul, Korea, Republic of