Incidence, Risk Factors, and Risk Model of Acute Kidney Injury After Thoracic Aortic Surgery
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Thoracic Aortic Surgery
- Sponsor
- Samsung Medical Center
- Enrollment
- 799
- Locations
- 1
- Primary Endpoint
- presence of Acute kidney injury
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
Postoperative acute kidney injury (AKI) is still one of the serious complications of thoracic aortic surgery, with incidence of 8 to 50 percent. Postoperative AKI significantly increases the morbidity and mortality of patients undergoing thoracic aortic surgery. Previous studies for AKI after DHCA reported confounding results due to different criteria of AKI. Therefore, the investigators tried to evaluate the incidence and risk factors of AKI after thoracic aortic surgery according to the diagnostic criteria and staging system of AKI reported from acute kidney injury network. The investigators also tried to develop a risk model with scoring system of AKI and evaluate the performance of the risk model.
Detailed Description
Significant improvement of morbidity and mortality has been achieved during last three decades since developing deep hypothermic circulatory arrest (DHCA). However,postoperative acute kidney injury (AKI) is still one of the serious complications of thoracic aortic surgery, with incidence of 8 to 50 percent. Postoperative AKI significantly increases the morbidity and mortality of patients undergoing thoracic aortic surgery. Previous studies for AKI after DHCA reported confounding results due to different criteria of AKI. Therefore, the investigators tried to evaluate the incidence and risk factors of AKI after thoracic aortic surgery according to the diagnostic criteria and staging system of AKI reported from acute kidney injury network (2007). The investigators also tried to develop a risk model with scoring system of AKI and evaluate the performance of the risk model.
Investigators
Sangmin M. Lee
Professor
Samsung Medical Center
Eligibility Criteria
Inclusion Criteria
- •patients who underwent thoracic aortic surgery during 1994 to 2010 period
Exclusion Criteria
- •patients who had previous renal failure before aortic surgery
Outcomes
Primary Outcomes
presence of Acute kidney injury
Time Frame: 1 time, within 48 hours of aortic surgery
diagnosis of AKI if the record of patient meet one of the below criteria 1. abrupt (within 48 hours) reduction in kidney function currently defined as 2. absolute increase in serum creatinine of more than or equal to 0.3 mg/dl (≥ 26.4 μmol/l), 3. a percentage increase in serum creatinine of more than or equal to 50% (1.5-fold from baseline), or 4. a reduction in urine output (documented oliguria of less than 0.5 ml/kg per hour for more than six hours)