A Multicenter, Randomized, Double-blind, Placebo-controlled Phase IIa Study to Explore the Efficacy, Safety, and Pharmacokinetic Profile of HWH486 in Adults With Chronic Spontaneous Urticaria(CSU)

Hubei Biological Medicine Industrial Technology Institute Co., Ltd.1 site in 1 country120 target enrollmentDecember 13, 2023

ConditionsChronic Spontaneous Urticaria

InterventionsHWH486 Placebo

DrugsHWH486 Placebo

Overview

Phase: Phase 2
Intervention: HWH486
Conditions: Chronic Spontaneous Urticaria
Sponsor: Hubei Biological Medicine Industrial Technology Institute Co., Ltd.
Enrollment: 120
Locations: 1
Primary Endpoint: Change in Urticaria Activity Score (UAS) over a 7-day period (UAS7)
Status: Recruiting
Last Updated: 2 years ago

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Sites Similar Trials

Overview

Brief Summary

This is a multicenter, randomized, double-bind and placebo-controlled phase IIa dose-finding study to assess the safety and efficacy of HWH486 in adults with chronic spontaneous urticaria (CSU). In addition, the pharmacokinetic characteristics will also be investigated.

Registry

clinicaltrials.gov

Start Date

December 13, 2023

End Date

January 2026

Last Updated

2 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Hubei Biological Medicine Industrial Technology Institute Co., Ltd.

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Age ≥18, ≤70 years old;
•Participants with chronic spontaneous urticaria (CSU) at the time of randomization as defined by the following: presence of itch and hives for ≥ 6 consecutive weeks prior to screening, despite second generation H1-antihistamine during this period; Urticaria Activity Score (UAS7) (range 0-42) ≥16, Hives Severity Score (HSS7) (range 0-21) ≥ 6 and Itch Severity Score (ISS7) (range 0-21) ≥ 6 during 7 consecutive days prior to randomization; CSU duration ≥6 months prior to screening (defined as the onset of CSU as determined by the investigator based on all available supporting documentation).
•Willing and able to complete the Urticaria Participant Daily eDiary (UPDD) for the duration of the study;
•Willing to take background medication and emergency medication according to the study protocol.
•Written informed consent signed voluntarily by the patient or their legal representatives.

Exclusion Criteria

•Previous use of HWH486 or other Bruton's tyrosine kinase(BTK) inhibitors;
•Participants having a predominant or sole trigger of their chronic urticaria (chronic inducible urticaria);
•Any other skin disease associated with chronic itching that might influence in the investigator's opinion the study evaluations and results, e.g. atopic dermatitis, bullous pemphigoid, dermatitis herpetiformis, senile pruritus or psoriasis
•With symptoms or signs of progressive or uncontrolled kidney, liver, blood, gastrointestinal, endocrine, lung, heart, neurological, psychiatric, or brain disease, or with a history of gastrointestinal bleeding that is associated with a significant risk of bleeding or coagulopathy, or is clinically significant (such as requiring hospitalization or blood transfusion), or with other chronic medical conditions that are not eligible for participation in this clinical trial, or having a history of malignancy, other than non-metastatic basal cell carcinoma or skin squamous cell carcinoma or carcinoma in situ of the cervix with appropriate treatment and no signs of recurrence;
•Clinically important laboratory test indicators are abnormal, including: abnormal blood routine: hemoglobin (Hb) \< 100g/L, or white blood cell count (WBC) \< 3.5×10\^9/L; Abnormal liver function: aspartate aminotransferase (AST) ≥1.5×ULN, or alanyl aminotransferase (ALT) ≥1.5×ULN, or total bilirubin (TBIL) ≥1.5×ULN; Abnormal renal function: creatinine (Cr) ≥1×ULN; any other laboratory test indicators that researchers think may affect the evaluation of test results;
•Active and uncontrolled viral and bacterial infections at the time of screening, such as human immunodeficiency virus(HIV), hepatitis B virus(HBV), hepatitis C virus (HCV), syphilis, tuberculosis test results, or if there are any clinical symptoms of bacterial, viral, parasitic or fungal infection requiring treatment;
•Pregnant or breastfeeding women; having pregnancy plans during the clinical trial and within 1 month after the last dose, and do not want to take medically accepted reliable contraceptive methods;
•History of allergy to any investigational therapeutic drug or its excipients;
•History or evidence of alcohol or drug abuse within the six months prior to randomization;
•Use of other immunosuppressive drugs, including but not limited to hydroxychloroquine, methotrexate, cyclosporin A, cyclophosphamide, tacrolimus, mycophenolate, tripterygium, and compound glycyrrhizin, within 30 days or 5 half-lives (whichever is older) prior to screening;

Arms & Interventions

HWH486

Intervention: HWH486

Placebo

Intervention: Placebo

Outcomes

Primary Outcomes

Change in Urticaria Activity Score (UAS) over a 7-day period (UAS7)

Time Frame: Baseline, Week 4

Weekly Urticaria Activity Score (UAS7; range 0-42; higher scores reflect greater disease activity)

Secondary Outcomes

Change in Hive Severity Score (HSS) over a 7-day period (HSS7)(Baseline to Week 4)
Change in Itch Severity Score (ISS) over a 7-day period (ISS7)(Baseline to Week 4)