Comparision of two doses of a medicine for treating acute asthma attack in children between age of 2 to 5 years
- Conditions
- Other and unspecified asthma,
- Registration Number
- CTRI/2020/08/027064
- Lead Sponsor
- Jawaharlal Institute of Pondicherry Medical Education and Research
- Brief Summary
Purpose of study:comparing two doses of a drug called magnesiumsulphate given through vein anddetermining which is effective for treating a severe case of asthma in children of 2 to 5 years of age.
- **Procedure/methods of the study:** If yourchild is 2 to 5 years of age with severe breathing difficulty due to asthmainitial emergency treatment will be given and again condition will bereassessed. If breathing difficulty is still severe, your child will beenrolled in the study and be given a drug called magnesium sulphate injectionwill be given. Your child will be allotted to one group randomly among the tworesearch groups. For one group 25mg/kg dose of drug will be given. Other groupwill receive 50mg/kg. As a parent you will not know the dose of drug that isadministered. Condition will be assessed at every hour till four hours. Even atthe end of four hours if the respiratory difficulty is not improving then yourchild`s treatment will be intensified as per your treating doctor in aintensive care setting.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- All
- Target Recruitment
- 20
Children with acute severe asthma with PRAM score 8 or more and continue to be 8 or more one hour post intervention.
Clinical suspicion of pneumonia Acute kidney injury or hypotension Congenital heart disease and structural airway anomalies that produce wheeze.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Proportion of children in whom intensive care admissions are prevented During period of hospitalization for study half an hour, two hours, four hours
- Secondary Outcome Measures
Name Time Method To correlate serum magnesium levels to the amount of magnesium sulphate infused and clinical outcome one hour Before and one hour after injecting magnesium Side effects of intravenous magnesium sulfate in above age group. During hospital stay.
Trial Locations
- Locations (1)
Jawaharlal Institute of Pondicherry Medical Education and Research
🇮🇳Pondicherry, PONDICHERRY, India
Jawaharlal Institute of Pondicherry Medical Education and Research🇮🇳Pondicherry, PONDICHERRY, IndiaMonicaPrincipal investigator8978446854csm.chakicherla@gmail.com