Study to know the safety and effectiveness of blood pressure supporting and brain pressure reducing drugs through the smaller peripheral veins

Completed

Conditions: Patients more than 18 years of age admitted to ICU requiring single Vasoactive medication or hypertonic saline through Peripheral Intravenous line.

Registration Number: CTRI/2018/05/013964

Lead Sponsor: Bangalore Baptist Hospital

Brief Summary: Vasoactive medications (VM) andhypertonic saline infusion are indicated in most of intensive care unit (ICU)patients. Both are usually recommended to be infused through centralvenous catheter (CVC) access, as the infusion through Peripheral Intravenous(PIV) line can cause local tissue injury due to extravasation of the drug.However insertion of CVC access itself is associated with complicationsincluding risk of bleeding, embolism, pneumothorax, catheter related bloodstream infections etc. CVC access also adds to the increased cost during ICUstay and delay in initiating treatment. In our ICU, we usually start with PIVline and we do not encounter problems. In this study, wehypothesise that VM and 3% S infusion is feasible and safe through peripheralintravenous route in lower concentrations and we want to conduct thisprospective observational study for confirmation of this hypothesis.

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 230

Inclusion Criteria

Patients more than 18 years of age admitted to ICU requiring single vasoactive medications or 3% Saline through Peripheral Intravenous line with either Mean arterial pressure (MAP) < 65 mmHg orSystolic blood pressure (SBP) < 90 mmHg or Cerebral oedema or raised ICP.

Exclusion Criteria

Patients already having Central Venous Catheter access.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Effectiveness of peripheral intravenous (PIV) line in administering vasoactive medications and hypertonic saline infusion in critically ill patients.	After stopping infusion through the peripheral intravenous line ( It can either be after clinical improvement or death or central venous catheter placement )

Secondary Outcome Measures

Name	Time	Method
Reason for insertion of central venous catheter access	Total time of infusion to develop extravasation and its association with site and size of peripheral intravenous line

Trial Locations

Locations (1): Bangalore Baptist Hospital
🇮🇳
Bangalore, KARNATAKA, India
Bangalore Baptist Hospital
🇮🇳Bangalore, KARNATAKA, India
Dr Prashant Kumar
Principal investigator
9920171486
prammcian@gmail.com