Effect of reduced water intake and removing excess body water actively by medicine increasing urine output on critically ill childre

Not Applicable

• Conditions: Health Condition 1: I958- Other hypotension

• Registration Number: CTRI/2018/08/015456
• Lead Sponsor: Dr Kaushik Maulik

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

1. All ventilated children between 2 completed months and 7 completed years admitted to PICU will be included

2. The included children must have received at least one fluid bolus

3. Must have achieved hemodynamic stability at enrolment defined by:

MAP >5th centile

CRT <2 seconds

Not required any more fluid bolus or inotropes in last 12 hours

Exclusion Criteria

1. Child with severe acute malnutrition (SAM)

2. Child with decompensated chronic liver disease and chronic kidney disease on RRT

3. Child with clinically suspected cardiogenic shock/myocarditis/acquired and congenital heart diseases in CCF

4. Children undergoing treatment for raised ICP with fluid restriction

5. Children with no evidence of fluid overload as assessed by body weight(defined as 10% increase from admission weight)

6. Children with severe anemia and hypoalbuminemia

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare the outcome of mechanically ventilated children undergoing fluid restriction and active fluid removal as compared to those with conventional fluid management in terms of daily Pediatric logistic organ dysfunction score (PELOD)Timepoint: This will be measured till 48 hours of sustaining nil balance or cessation of mechanical ventilation in the intervention group or till cessation of mechanical ventilation in the control group

Secondary Outcome Measures

Name	Time	Method
1. ICU mortality <br/ ><br>2. Duration of PICU stay <br/ ><br>3. Ventilator free days <br/ ><br>4. Requirement of RRTTimepoint: These will be measured till child is shifted out of PIC