Metabolic Effects of Subchronic Dopamine D2 Receptor Blockade by Antipsychotic Drugs in Healthy Humans

Not Applicable

Completed

• Conditions: Insulin Resistance; Dyslipidemia
• Interventions: Drug: olanzapine; Drug: Haloperidol

• Registration Number: NCT00625170
• Lead Sponsor: Leiden University Medical Center

Brief Summary

We hypothesized that short-term treatment with AP drugs induces insulin resistance through a mechanistic route that is independent of weight gain and that atypical drugs exert stronger effects than typical compounds in this respect. We therefore treated healthy non-obese men with olanzapine (atypical AP) or haloperidol (typical AP) for 8 days, and studied the impact of these interventions on glucose and lipid metabolism by hyperinsulinemic euglycemic clamp, isotope dilution technology and indirect calorimetry.

Detailed Description

Not available

Study Timeline

• Status Verified: 2004-03
• Study Start: 2004-05
• Primary Completion: 2004-12
• Study Completion: 2004-12
• Study First Submitted: 2008-02-19
• Study First Submitted QC: 2008-02-19
• Last Update Submitted: 2008-02-19
• Study First Posted: 2008-02-28
• Last Update Posted: 2008-02-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 11

Inclusion Criteria

• Healthy men, with and without a positive family history of schizophrenia.
• 20 kg/m2 < BMI < 26 kg/m2
• Age 20-40 years
• Fasting plasma glucose < 6 mmo/L

Exclusion Criteria

• FPG > 6 mmol/L
• BMI > 26 kg/m2
• Psychiatric disorders and/or use of antipsychotic or antidepressants drugs at present or in the past.
• Any significant chronic disease
• Renal, hepatic or endocrine disease
• Use of medication known to influence lipolysis and/or glucose metabolism
• Total cholesterol > 7mmol/L and/or triglycerides > 2 mmol/L
• Recent weight changes or attempts to loose weight (> 3 kg weight gain or loss, within the last 3 months)
• Difficulties to insert an intravenous catheter
• Smoking (current)
• Severe claustrophobia (ventilated hood)
• Recent blood donation (within the last 2 months)
• Recent participation in other research projects (within the last 3 months), participation in 2 or more projects in one year
• Extensive sporting activities (more than 10 hours of exercise per week)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
1	olanzapine	Healthy men
2	olanzapine	Healthy men with a positive family anamneses of schizophrenia
2	Haloperidol	Healthy men with a positive family anamneses of schizophrenia

Primary Outcome Measures

Name	Time	Method
To determine the effect of subchronic olanzapine and haloperidol treatment on HGO, whole body peripheral glucose disposal, fatty acid flux and fuel oxidation.	8 days

Trial Locations

Locations (1)

Leiden University Medical Center; 🇳🇱 Leiden, Netherlands