Arginine supplementation in severe sepsis: effects on metabolism and microcirculatio

Completed

• Conditions: Sepsis, Septic shock; Infections and Infestations; Other septicaemia

• Registration Number: ISRCTN56258935
• Lead Sponsor: utrition and Toxicology Research Institute Maastricht (NUTRIM) (Netherlands)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2006-01-27
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

1. Written informed consent from close relative
2. Age >18 years
3. Patient meets the general criteria for severe sepsis or septic shock (international published sepsis definitions), diagnosed less than 48 hours prior to study inclusion
4. Patient must be relatively hemodynamically stable, defined as stable blood pressure (variation in mean arterial pressure <15 mmHg) for 2 hours without necessity of increasing the vasopressor dose, inotropic support or rate of fluid administration
5. Systemic arterial catheter in place with continuous pressure monitoring
6. Patients in whom the clinician is prepared to provide full life support during the duration of the study

Exclusion Criteria

1. Shock due to any cause other than sepsis (e.g. drug reaction or drug overdose, pulmonary embolus, burn injury, severe blood loss etc.)
2. Prolonged or high dose corticosteroid use
3. Liver cirrhosis
4. Chronic pancreatitis
5. Insulin-dependent diabetes mellitus
6. Metastases, haematological, malignancies or chemotherapy
7. Patients on dialysis (CVVH or other)
8. Pre-existent urea cycle disorders or renal failure

Study & Design

• Study Type: Interventional
• Study Design: Not specified