ISRCTN56258935已完成不适用

Arginine supplementation in severe sepsis: effects on metabolism and microcirculatio

utrition and Toxicology Research Institute Maastricht (NUTRIM) (Netherlands)0 个研究点目标入组 16 人开始时间: 2006年1月27日最近更新: 2015年1月13日

适应症

试验速览

暂无简介。

•1. Written informed consent from close relative
•2. Age >18 years
•3. Patient meets the general criteria for severe sepsis or septic shock (international published sepsis definitions), diagnosed less than 48 hours prior to study inclusion
•4. Patient must be relatively hemodynamically stable, defined as stable blood pressure (variation in mean arterial pressure <15 mmHg) for 2 hours without necessity of increasing the vasopressor dose, inotropic support or rate of fluid administration
•5. Systemic arterial catheter in place with continuous pressure monitoring
•6. Patients in whom the clinician is prepared to provide full life support during the duration of the study

•1. Shock due to any cause other than sepsis (e.g. drug reaction or drug overdose, pulmonary embolus, burn injury, severe blood loss etc.)
•2. Prolonged or high dose corticosteroid use
•3. Liver cirrhosis
•4. Chronic pancreatitis
•5. Insulin-dependent diabetes mellitus
•6. Metastases, haematological, malignancies or chemotherapy
•7. Patients on dialysis (CVVH or other)
•8. Pre-existent urea cycle disorders or renal failure

发起方

utrition and Toxicology Research Institute Maastricht (NUTRIM) (Netherlands)