NCT01546155已完成不适用
The Influence of Pressure Pain on [11C]Diprenorphine Binding Potentials
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 11
- 试验地点
- 2
- 主要终点
- PET/MRI Brain Activation
研究概览
简要总结
Healthy volunteers aged 21 to 50 are needed for a research study investigating whether pain will alter the binding properties of ([11C]diprenorphine), a molecule that can be used during brain imaging. Positron Emission Tomography (PET) and functional Magnetic Resonance (fMRI) imaging will be used in this study.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy male and female adults, 21 to 50 years of age
- •No contraindications to fMRI and PET scanning
- •Within 15% of ideal body mass index (BMI)
排除标准
- •Current significant medical, neurological, or psychiatric illness as assessed by the Physician Investigators
- •Women who are pregnant or breast feeding, have gone through menopause, and/or have irregular menstrual cycles
- •Claustrophobia
- •History of head trauma
- •Instability of responses to experimental pain (See Study Procedure Section Part II)
- •History of asthma
- •Use of psychotropic drugs or hormone treatments (including hormonal birth control) within one year of date of consent
- •History of smoking
- •Routine exercise in excess of one hour per day and/or three times per week
- •Non-fluent English speaker
结局指标
主要结局
PET/MRI Brain Activation
时间窗: day one
Simultaneously collect fMRI-PET data in humans to investigate the change between bold signal evoked by pressure pain and bold signal evoked by non-painful pressure. The PET analyses generates one value per 120 minutes. This value is compared to the other 120 minute scan PET value in order to reflect the change.
次要结局
未报告次要终点
研究者
Jian Kong
Assistant Professor
Massachusetts General Hospital
研究点 (2)
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