How is oral desensitization in patients with milk allergy
- Conditions
- immunotherapyanaphylaxisC20.543.480.370.500
- Registration Number
- RBR-2fbw8dt
- Lead Sponsor
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruitment completed
- Sex
- Not specified
- Target Recruitment
- Not specified
Patients over three years old; diagnosis of persistent IgE-mediated cows milk allergy with compatible and reproducible immediate symptoms for less than one year or recent positive oral test (one year interval); severe cows milk allergy: as reported or recorded in the medical record of anaphylaxis history; specific IgE for milk, alpha-lactalbumin, beta-lactoglobulin or casein positive by the ImmunoCAP method; positive prick test with a diameter greater than or equal to three millimeters of the negative control for milk in natura; and possess self-injecting adrenaline
Patient diagnosed with cows milk allergy with some degree of tolerance; patient with non-IgE-mediated cows milk allergy; patient with eosinophilic esophagitis prior to immunotherapy; patients with uncontrolled asthma; patients with cardiovascular diseases or other diseases and therapies that contraindicated the use of adrenaline; patients with serious systemic diseases such as autoimmune diseases and malignant neoplasms; and patients and/or caregivers who have difficulty understanding the purpose of treatment, following treatment instructions, and recognizing and treating adverse reactions (not familiar with the action plan)
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The expected outcome is for the patient to consume milk without reactions and reduction of clinical parameters
- Secondary Outcome Measures
Name Time Method <br>Secondary outcomes are not expected