Thrombo-inflammation Des Maladies Neurovascualires aiguës : définition de Nouvelles Cibles thérapeutiques (TARGETS)
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 499
- 主要终点
- Investigation of changes in thrombo-inflammatory marker concentrations between patients and over time.
研究概览
简要总结
The objective of this observational study is to compare the relative concentrations of various thrombo-inflammatory markers at different follow-up time points in:
- patients with or without delayed cerebral ischemia after subarachnoid hemorrhage, and
- patients with or without rapid progression of necrotic volume after an ischemic stroke due to large- or medium-vessel occlusion in the anterior circulation.
The main question this study aims to answer is: How do thrombo-inflammatory marker concentrations evolve over time and differ between patients? Researchers will compare patients with or without delayed cerebral ischemia after subarachnoid hemorrhage, as well as patients with or without rapid progression of necrotic volume following an ischemic stroke due to large- or medium-vessel occlusion in the anterior circulation, to determine whether there are differences in thrombo-inflammatory marker concentrations and in their evolution over time.
Participants will undergo blood sampling at five different time points. In addition, participants will complete a Montreal Cognitive Assessment (MoCA) questionnaire during the 3-month follow-up visit.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients aged 18 years or older
- •Admitted within 8 hours of an acute ischemic stroke (AIS) due to large-vessel occlusion (LVO) or medium-vessel occlusion (MeVO) of the anterior circulation, with a NIHSS (National Institutes of Health Stroke Scale) score > 5 (M1, M2, M3, A1, A2, A3, P1, P2)
- •Or admitted within 36 hours of acute symptoms related to aneurysmal subarachnoid hemorrhage (SAH)
排除标准
- •Patients with pre-existing functional and/or cognitive disability (modified Rankin Scale, mRS > 1)
- •Patients under legal protection or guardianship
- •Patients with secondary hemorrhagic transformation of an acute ischemic stroke
- •Patients with acute ischemic stroke and NIHSS > 5 without LVO or MeVO of the anterior circulation on imaging will be secondarily excluded. Perfusion imaging will not be performed as part of the research protocol. Excluded patients will be replaced.
研究组 & 干预措施
healthy volunteer
healthy volunteer
AIC
Patient with rapid progression of necrotic volume after an ischemic stroke due to large- or medium-vessel occlusion in the anterior circulation
HSA
Patient with delayed cerebral ischemia after subarachnoid hemorrhage
结局指标
主要结局
Investigation of changes in thrombo-inflammatory marker concentrations between patients and over time.
时间窗: From enrollment to Month 3 visit
Investigation of changes in thrombo-inflammatory marker concentrations between patients and over time.
次要结局
未报告次要终点
研究者
François Delvoye
Doctor
Centre Hospitalier Universitaire de Liege