ISRCTN37548161已完成未知
The effects of green tea and coffee polyphenols on insulin sensitivity and secretion and cardiovascular function in overweight and obese women with Polycystic Ovary Syndrome (PCOS) and insulin resistance
Medical Research Council - Human Nutrition Research (UK)0 个研究点目标入组 12 人开始时间: 2014年4月16日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 12
研究概览
简要总结
2015 results presented at Experimental Biology conference in https://www.fasebj.org/doi/abs/10.1096/fasebj.29.1_supplement.lb271 (added 25/11/2019)
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- Female
入选标准
- •1. Otherwise healthy
- •2. Pre-menopausal, overweight or obese women (BMI = 25 kg/m2)
- •3. Aged16-45 years
- •4. With PCOS and insulin resistance (fasting insulin = 50 pmol/L)
排除标准
- •1. Smoking
- •2. History of substance abuse or alcohol consumption >14 units per week
- •3. Allergy or intolerance to the study supplements and/or foods
- •4. Professional athletes or those with self-reported high physical activity
- •5. Chronic, acute or active metabolic (including type 1 and type 2 diabetes mellitus) and inflammatory conditions, haematological disorders, or any other systemic illness of renal, hepatic or gastrointestinal origin
- •6. Active cancer or diagnosis of malignancy within the last five years
- •7. Major surgical operations interfering with the study outcomes within three months of screening
- •8. Medical treatment with the following agents: weight reduction medicines, insulin sensitizers, hormonal therapy, antihypertensive medicines, anti-dyslipidaemic agents, nitrate-derived agents, psychiatric drugs (only excluded if dose had been started/changed in the previous six months) or any other medication known to affect glucose/insulin metabolism, vascular/endothelial function, gastrointestinal system or central nervous system
- •9. Weight change > 10% over the last six months
- •10. Endocrine disorders such as adrenal hyperplasia, hyperprolactinaemia, Cushing?s syndrome, androgenic tumours, late onset of 21-hydroxylase deficiency, abnormal thyroid function or any other ovarian, adrenal or pituitary disorder not associated with PCOS
- •11. Pregnant, lactating, contemplating pregnancy or undergoing treatment to achieve pregnancy
- •12. Regular consumption of micronutrient and/or herbal and/or polyphenol supplements known to have an impact on insulin sensitivity/secretion and/or vascular/endothelial function
研究者
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