Comparison between chlorpromazine with olanzapine vs chlorpromazine alone in the treatment of hiccups in patients who had traumatic brain injury
Phase 2/3
Not yet recruiting
- Conditions
- Other specified disorders of nervous system in diseases classified elsewhere, (2) ICD-10 Condition: G998||Other specified disorders of nervous system in diseases classified elsewhere,
- Registration Number
- CTRI/2020/11/028823
- Lead Sponsor
- Trauma centre Banaras Hindu University
- Brief Summary
This is a prospective comparitive study between combination therapy vs mono therapy in the treatment of hiccups on traumatic brain injury patients
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- All
- Target Recruitment
- 90
Inclusion Criteria
Patients having intracranial injury confirmed by ct scan.
Exclusion Criteria
Pregnant patients Patients with diabetes/copd/hypertension Patient with end organ damage Refusal to participate.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Reduction in frequency of hiccups with combination vs monotherapy 4 weeks
- Secondary Outcome Measures
Name Time Method Easy weaning from ventilator due to the remission of hiccups 5 weeks
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie chlorpromazine and olanzapine's antihistaminergic effects in treating hiccups post traumatic brain injury?
How does combination therapy with chlorpromazine and olanzapine compare to standard-of-care treatments for intractable hiccups in G998 neurological patients?
Are there specific biomarkers that predict response to dopamine antagonist therapy for hiccups in traumatic brain injury populations?
What are the potential adverse events associated with chlorpromazine monotherapy versus combination therapy in post-TBI patients?
How do other dopamine receptor antagonists like haloperidol compare to chlorpromazine-based regimens for treating persistent hiccups in neurotrauma cases?
Trial Locations
- Locations (1)
Trauma centre, Banaras Hindu University
🇮🇳Varanasi, UTTAR PRADESH, India
Trauma centre, Banaras Hindu University🇮🇳Varanasi, UTTAR PRADESH, IndiaMeera srinivasanPrincipal investigator9566290935meera.srinivasan64@yahoo.com