To understand the effect of booster dose vaccine on covid inadequate/negative antibody auto immune negative patients

Not Applicable

• Conditions: Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhereHealth Condition 2: M199- Osteoarthritis, unspecified siteHealth Condition 3: M058- Other rheumatoid arthritis with rheumatoid factorHealth Condition 4: M468- Other specified inflammatory spondylopathiesHealth Condition 5: M329- Systemic lupus erythematosus, unspecifiedHealth Condition 6: M349- Systemic sclerosis, unspecified

• Registration Number: CTRI/2021/12/038928
• Lead Sponsor: Dr Padmanabha Shenoy

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 17 October 2022

Recruitment & Eligibility

• Status: Closed to Recruitment of Participants
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

Patient above 18 yrs to 80 yrs of age

2. Patients with diagnosed case of Autoimmune Rheumatic Disease

3. Patients who are on stable doses of immunosuppressants for more than 3 months and on stable doses of more than 3 weeks in case of steroids

4. Patients who are seronegative or suboptimal response after both doses of Covid 19 vaccine

5. Patients who are willing to provide informed consent and to comprehend with the study

Exclusion Criteria

1. Patients with unstable disease activity and past history of flare following vaccinations.

2. Patients with non-repopulated peripheral B cell, if they have taken B cell depletion therapy 3. Patients with past history of Covid infection 4. Patients with history of allergic reaction to vaccine or its components

5. Patients who received any live vaccine within 2 months prior the study. 6. Patients with history of arterial/ venous thrombosis, demyelinating syndromes or diagnosed case of vasculitis

Study & Design

• Study Type: Interventional
• Study Design: Not specified