Association Between Fibrinogen-to-albumin Ratio and Delirium After Deep Brain Stimulation Surgery in Parkinson's Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 226
- 试验地点
- 1
- 主要终点
- CAM score
研究概览
简要总结
Postoperative delirium (POD) remains one of the most common neuropsychiatric complications after deep brain stimulation (DBS) surgery. The fibrinogen-to-albumin ratio (FAR) has been shown to significantly correlate with prognosis of many diseases associated with inflammation, but the relationship between FAR and POD is unclear. The investigators aimed to investigate the association between POD and FAR in Parkinson's disease (PD) patients receiving DBS surgery. For this aim, the present study was conducted to provide a new method for the early recognition and perioperative management of delirium after DBS surgery in PD patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 55 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Over 55 years old
- •American Society of Anesthesiologists (ASA) physical status I-III
- •Bilateral subthalamic nucleus deep brain stimulation surgery
排除标准
- •Preoperative delirium
- •Missing preoperative laboratory parameters on fibrinogen or albumin
- •Persistent infectious diseases
- •Coagulopathy and autoimmune-illness or malignancies
结局指标
主要结局
CAM score
时间窗: Postoperative day 3
Positive CAM score means that patient developed delirium after surgery. While negative CAM score means that patient did not suffer from delirium after surgery.
次要结局
- Mini-mental State Examination (MMSE) score(Before surgery)
- The level of fibrinogen-to-albumin ratio (FAR) in peripheral blood.(Before surgery)
- MMSE score(postoperative 72 hour)
研究者
Wen-bin Lu, MD
Principal Investigator
Changhai Hospital