Periostin and Non-Surgical Periodontal Treatment

Not Applicable

Completed

• Conditions: Periodontal Diseases
• Interventions: Procedure: Non-Surgical Periodontal Treatment

• Registration Number: NCT04332965
• Lead Sponsor: Kırıkkale University

Brief Summary

A total of 90 subjects, 30 patients with chronic periodontitis, 30 with gingivitis and 30 periodontally healthy subjects were included. Patients with periodontal disease received non-surgical periodontal treatment. Gingival crevicular fluid periostin levels were assessed at baseline, at the 6th week and the 3rd month after treatment.

Detailed Description

Periostin is commonly found in collagen-rich tissues, which is thought to affect the production of collagen fibers. Additionally, periostin is synthesized in tissues exposed to constant mechanical forces such as the periosteum, periodontal ligament, tendon, heart valve and skin. Periostin mediates inflammation and fibrosis during diseases of various organs, including the heart, lung, kidney, skin, liver, skeletal muscle and retina.

This study evaluated periostin levels in gingival crevicular fluid from patients with chronic periodontitis, gingivitis and periodontally healthy as well as the effect of non-surgical periodontal treatment on gingival crevicular fluid periostin levels.

Study Timeline

• Study Start: 2017-01
• Primary Completion: 2018-01
• Study Completion: 2018-04
• Status Verified: 2020-04
• Study First Submitted: 2020-04-01
• Study First Submitted QC: 2020-04-02
• Last Update Submitted: 2020-04-02
• Study First Posted: 2020-04-03
• Last Update Posted: 2020-04-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• Clinical diagnosis of chronic periodontitis
• Clinical diagnosis of gingivitis
• Clinical diagnosis of periodontal health

Exclusion Criteria

• have any systemic disease
• to be alcohol consumer
• to receive any periodontal therapy in the past 6 months
• to take any drugs regularly
• to be pregnant and/or lactate

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Patients with chronic periodontitis	Non-Surgical Periodontal Treatment	Patients with CP (n=30) had teeth with 30% periodontal bone loss and ≥ 2 non-adjacent sites per quadrant with probing depth (PD) ≥ 5 mm and bleeding on probing.
Patients with gingivitis	Non-Surgical Periodontal Treatment	Participants with G (n=30) had gingival index ≥ 2 and other inflammation signs.

Primary Outcome Measures

Name	Time	Method
Change in periostin	Baseline, 6th week and 3rd month	Total amount of Periostin (pg/30 sec) in gingival crevicular fluid

Secondary Outcome Measures

Name	Time	Method
Change in periodontal clinical parameter	Baseline, 6th week and 3rd month	Clinical attachment level (mm) (from cemento-enamel junction to the base of periodontal pocket)