NCT01838785已完成2 期
Positron-Emission Tomography With Vesicular Monoamine Transporter Ligand ([18F]-DTBZ) In Healthy Elderly And Young Subjects
Chang Gung Memorial Hospital0 个研究点目标入组 25 人开始时间: 2012年7月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 25
- 主要终点
- Age-Dependent Change in Striatal 18F-DTBZ Uptake of Healthy Subjects.
研究概览
简要总结
A total 25 healthy subjects will be included in this study. Subjects between 20 and 80 years of age may be eligible for this study. Candidates are screened with a medical history and physical examination, and blood test.
详细描述
The primary objective of this protocol is to assess the possible age-dependent decline in striatal 18F-DTBZ uptake of healthy subjects.
This study is expected to be completed in a period of 2 years.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male or female age 20 years to 80 years.
- •Subjects without significant neuropsychiatric disorder after evaluation by Neurologist.
- •Subjects who provide a written informed consent prior to study entry. If the subject is incapable of informed consent, the caregiver may consent on behalf of the subject (the subject must still confirm assent).
排除标准
- •Pregnancy and breast feeding.
- •Significant recent (within 6 months) history of neurological (including stroke and brain trauma) or psychiatric disorder.
- •Alcohol or substance abuse within last year.
- •Parkinson's disease or other brain degenerative disease (spinocerebellar ataxia, Wilson's disease, hydrocephalus, multiple infarction, history of severe head injury or intracranial operation.
- •Unable to stay still in the MRI or PET scanner for 30 minutes.
研究组 & 干预措施
18F-DTBZ AV-133
Experimental
18F-DTBZ AV-133 imaging
干预措施: 18F-DTBZ AV-133 (Drug)
结局指标
主要结局
Age-Dependent Change in Striatal 18F-DTBZ Uptake of Healthy Subjects.
时间窗: two years
次要结局
- The Test/Retest 18F-DTBZ PET Measurements of VMAT2 Binding in Healthy Subjects.(two years)
研究者
相似试验
尚未招募
Unknown
Can a breath hold PET/CT improve the detection and assessment of metastatic liver lesions?ACTRN12624000422527Tony Bose26
已完成
1 期
Positron Emission Tomography Study in Healthy Subjects to Determine the Relationship Between Plasma Concentration and Brain Target Occupancy of ASN51NCT06390098Asceneuron S.A.3
已完成
不适用
Clinical study using positron emission tomography(PET)brain tumor,epilepsy,multiple sclerosis, neuromyelitis,Duchenne musclar dystrophy,Alzheimer's disease,Down Syndrome,HydrocephalusJPRN-UMIN000005626Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata100
已完成
2 期
18F-DTBZ PET and Multi-modal MRI in the Patients With Vascular ParkinsonismVascular ParkinsonismNCT02195154Chang Gung Memorial Hospital13
已完成
2 期
Cognitive Decline and Alzheimer's Disease in the Dallas Lifespan Brain StudyAlzheimer DiseaseCognitive DeclineNCT04080544Neil M Rofsky, MD, MHA125