Optimal Initiation of Helicobacter Pylori Eradication After Endoscopic Resection
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 149
- 试验地点
- 1
- 主要终点
- H. pylori eradication rate according to timing of therapeutic regimen after endoscopic resection
研究概览
简要总结
After endoscopic resection (ER) of gastric tumors, eradication of Helicobacter pylori (H. pylori) infection is advised to reduce metachronous recurrence. However, few studies have addressed factors influencing H. pylori eradication rates in the aftermath of ER, and none have focused on the optimal timing of therapy to eradicate H. pylori post-ER.Therefore, the investigators will conduct to evaluate whether differences in timing of eradication therapy after ER of gastric tumors.
详细描述
Uur previous retrospective study unveiled that administering eradication treatment within 2 weeks post-ESD during the active reparative phase of ESD-induced ulcers yielded a markedly higher success rate compared to treatment post-8 weeks during the scarring phase of ESD-induced ulcers.Therefore, we conducted a multicenter, randomized, prospective study to ascertain whether the optimal timing of eradication post-ESD could influence the eradication success rate.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients underwent endoscopic resection of gastric neoplasm
- •patients who diagnosed as H. pylori infection by rapid urease test
排除标准
- •Histories of gastric surgery
- •Histories of prior H. pylori eradication therapy
- •Use of drugs affecting H. pylori positivity (proton pump inhibitor, histamine-2 receptor blocker, or antibiotics) within the preceding 2 weeks
结局指标
主要结局
H. pylori eradication rate according to timing of therapeutic regimen after endoscopic resection
时间窗: The success of H. pylori eradication was determined using a urea breath test conducted 13 weeks ± 5 days after ESD
The success of H. pylori eradication was determined using a urea breath test conducted
次要结局
未报告次要终点
研究者
Young Hoon Youn
Department of Internal Medicine,
Gangnam Severance Hospital