The effectiveness of Vonoprazan comparing with high dose proton pump inhibitor in recurrence bleeding rate of high risk peptic ulcer: A randomised controlled study
Phase 3
Recruiting
- Conditions
- Bleeding peptic ulcerProton pump inhibitor, Potassium competitive acid blocker, Peptic ulcer disease, Upper gastrointestinal bleeding, Vonoprazan, Mortality, Rebleeding
- Registration Number
- TCTR20210227002
- Lead Sponsor
- Faculty of Medicine, Prince of Songkhla University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
1.Age 15-70 years old
2.Bleeding peptic ulcer which is achieved hemostasis by the endoscopic intervention(if adrenaline injection is used combination therapy should be applied)
3.Feeding via oral
4.No active malignancy
Exclusion Criteria
1.Not achieve hemostasis by the endoscopic intervention
2.Pregnancy and lactation
3.Patient who receives protease inhibitor
4.Advanced cirrhosis CTP C
5.Patient with active cardiovascular disease
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Rebleeding rate 72 hours Rebleeding rate
- Secondary Outcome Measures
Name Time Method 28-day mortality 28 days 28-day mortality