The effectiveness of Vonoprazan comparing with high dose proton pump inhibitor in recurrence bleeding rate of high risk peptic ulcer: A randomised controlled study

Phase 3

Recruiting

• Conditions: Bleeding peptic ulcer; Proton pump inhibitor, Potassium competitive acid blocker, Peptic ulcer disease, Upper gastrointestinal bleeding, Vonoprazan, Mortality, Rebleeding

• Registration Number: TCTR20210227002
• Lead Sponsor: Faculty of Medicine, Prince of Songkhla University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-02-27
• Study Completion: 2024-02-26
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

1.Age 15-70 years old
2.Bleeding peptic ulcer which is achieved hemostasis by the endoscopic intervention(if adrenaline injection is used combination therapy should be applied)
3.Feeding via oral
4.No active malignancy

Exclusion Criteria

1.Not achieve hemostasis by the endoscopic intervention
2.Pregnancy and lactation
3.Patient who receives protease inhibitor
4.Advanced cirrhosis CTP C
5.Patient with active cardiovascular disease

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Rebleeding rate 72 hours Rebleeding rate

Secondary Outcome Measures

Name	Time	Method
28-day mortality 28 days 28-day mortality