Evaluation of the Relationship Between SLMAP and EPO Genetic Polymorphism and the Risk of Diabetic Retinopathy in Egyptian Diabetic Patients: A Case-Control Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 180
- 试验地点
- 1
- 主要终点
- Association of SLMAP gene polymorphism and the risk of confirmed diabetic retinopathy diagnosis
研究概览
简要总结
A case-control study to assess the association between the risk of diabetic retinopathy in Egyptians and genetic polymorphism of both EPO and SLMAP genes.
详细描述
Traditional environmental risk factors, such as glycemic control and duration of diabetes, failed to fully explain why some individuals remain protected while others progress to severe diabetic retinopathy.
Several studies suggest variations in diabetic retinopathy prevalence depending on racial background and genetic polymorphism.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 30 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age >30-60
- •Type 2 DM
- •Duration of diabetes from 5-10 years
- •Egyptian patients
排除标准
- •Other ophthalmic diseases not related to diabetes
结局指标
主要结局
Association of SLMAP gene polymorphism and the risk of confirmed diabetic retinopathy diagnosis
时间窗: At baseline (upon confirmed diagnosis of diabetic retinopathy)
the odds ratio of being diagnosed with diabetic retinopathy in those with SLMAP rs17058639 single nucleotide polymorphism compared to wild type
Association of EPO gene polymorphism and the risk of confirmed diabetic retinopathy diagnosis
时间窗: At baseline (upon confirmed diagnosis of diabetic retinopathy)
The odds ratio of being diagnosed with diabetic retinopathy in those with EPO rs551238 single nucleotide polymorphism compared to wild type
次要结局
- The association of confounding factors on the incidence of diabetic retinopathy(At baseline)
研究者
Rana Sayed Fouad
Principal investigator
Ain Shams University