Effects of Evolocumab on carotid plaque.

Not Applicable

• Conditions: carotid plaque

• Registration Number: JPRN-UMIN000028178
• Lead Sponsor: Iwate Medical University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-08-01
• Study Completion: 2019-03-31
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Not provided

Exclusion Criteria

1) History of coronary artery disease or valvular disease or heart failure of NYHA class 3 or higher 2) Arrhythmia with poor control within 3 months 3) High blood pressure with poor control(systolic blood pressure at rest > 180 mmHg) 4) Type 1 diabetes or poorly controlled diabetes (HbA1c > 9.0 %) 5) Creatine kinase is at least 3 times higher than normal upper limit. 6) History of PCSK9 inhibitor administration in the past. 7) History of administration of cyclosporine and steroid for more than 2 weeks within 3 months before entry of the study. 8) History of malignant tumor. 9) Active infectious diseases, renal failure, blood diseases, gastrointestinal diseases and metabolic diseases oher than diabetes / dyslipidemia 10) Pregnancy 11) Inability to evaluate by carotid ultrasonography by calcification. 12) Other conditions which the physician deems inappropriate.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in IMT from baseline to week 48.