Effects of Different Types of Obesity on Sperm Quality: A Cross-Sectional Study

Background: Obesity is a well-established risk factor for male infertility, yet the mechanisms underlying this association remain incompletely understood. Recent evidence suggests that the distribution of adipose tissue, particularly pudendal fat deposition, may have distinct effects on male reproductive health beyond overall body mass index (BMI). This cross-sectional study aims to elucidate the differential impact of various obesity types on sperm quality, shedding light on potential pathways for intervention and treatment of male infertility.

Objective: The primary objective of this study is to compare sperm quality parameters among three distinct groups: individuals with a normal BMI, obese individuals without pudendal fat deposition around the testicles, and obese individuals with pudendal fat deposition.

Study Design: This study will employ a cross-sectional design to recruit participants from [insert recruitment settings]. Participants will be categorized into three groups based on BMI and the presence of pudendal fat deposition. Sperm quality parameters, including count, motility, and morphology, will be assessed through semen analysis. Additionally, hormonal profiles related to reproductive health will be evaluated.

Inclusion Criteria: Male individuals with fertility needs with BMI within the specified ranges for normal weight and obesity will be eligible for participation. Participants must provide informed consent prior to enrollment.

Exclusion Criteria: Individuals with known medical conditions affecting fertility, such as cryptorchidism or primary testicular failure, will be excluded from the study. Participants currently undergoing treatment for infertility or with a history of recent exposure to factors known to affect sperm quality (e.g., chemotherapy, radiation therapy) will also be excluded.