Effect of N3-polyunsaturated fatty acids on peripheral insulin sensitivity

• Conditions: and total parenteral nutrition; Diabetes; 10018424

• Registration Number: NL-OMON34627
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

- male
- BMI 20-25 kg/m2
- Stable weight during 3 months before participation and during participation
- Normal physical activity with at most 2 times per week sport activities
- Non-smoking
- Caucasian

Exclusion Criteria

- any medical condition or use of medication
- DM type II in first degree relatives
- hypersensitivity to fish-, egg-, soya or peanut protein
- participation in other medical trials during 3 months prior to inclusion

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Glucose uptake (Rd),<br /><br>Plasma concentration of FFA, </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>-To study the accumulation of FA metabolites and components of the insulin<br /><br>signaling pathway after infusion of SMOFlipid<br /><br>- glucoregulatory hormones and inflammatory markers.</p><br>