Effect of a mouthwash containing Cinnamomum zeylanicum Blume (Cinnamon) for treatment of oral candidiasis
Not Applicable
- Conditions
- Oral candidiasis associated with the use of removable dental prosthesis.
- Registration Number
- RBR-33s6x5
- Lead Sponsor
- niversidade Federal da Paraíba
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Data analysis completed
- Sex
- Not specified
- Target Recruitment
- Not specified
Inclusion Criteria
Individuals aged 40 to 70 years with oral candidiasis and who wore removable dentures.
Exclusion Criteria
Individuals who had undergone topical and/or systemic antimicrobial treatment or were sensitive to C. zeylanicum EO or nystatin were excluded.
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Presentation of the expected outcome: improvement of clinical aspects (coloration, texture, presence of pseudomembrane and edema) of the palatal mucosa, verified from clinical examination by visual inspection and palpation before and after the study. Data collected before and after 15 days of use of the experimental and control products.<br>According to the parameter defined for the sample calculation, a cure rate of 80% is expected.;Presentation of observed outcome: From the results obtained and statistical analysis performed, there was a significant clinical improvement (p = 0.0139, Wilcoxon test), with a 55.6% cure rate.
- Secondary Outcome Measures
Name Time Method Presentation of expected secondary outcome: decrease in the number of colony forming units of Candida spp., Verified from mycological examination of the affected mucosa, observed before and after use of the experimental product.;Presentation of the secondary endpoint observed: No change in the number of colony forming units of Candida spp., Verified from mycological examination of the affected mucosa, observed before and after use of the experimental product.