Behavioural Addiction and Genetics in Parkinson's Disease
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 332
- Locations
- 1
- Primary Endpoint
- Allele frequency of 50 genetic markers (polymorphisms) will be compared between cases and controls.
Study Overview
Brief Summary
The " Behavioural Addiction and Genetics in Parkinson's Disease " study (BADGE-PD) is a national (France), multicenter, genetic association, case-control study to identify genetic factors associated with behavioural addiction (or Impulse Control Disorders, ICD) related to dopamine agonists treatment in Parkinson's disease (PD). Polymorphisms of candidate genes supposed to be involved in this adverse effect will be compared in 200 PD patients with ICD (n=200) and 200 matched PD patients without ICD (n=200).
Detailed Description
Objective: To identify susceptibility genes to impulse control disorders in Parkinson's Disease.
Study design: Genetic association study.
Primary objective:
To identify the susceptibility genes in behavior addiction in Parkinson's Disease
Secondary endpoints:
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Allele frequency of 50 genetic markers (polymorphisms) will be compared between cases and controls.
Time Frame: baseline
Secondary Outcomes
- Total UPDRS (Unified Parkinson's Disease Rating Scale) score(baseline)
- number of patients with a diagnostic of ICD according to the MINI(baseline)
- Total score of the MMSE (Mini Mental State Examination)(baseline)
- Sub scores at the temperament and Character Inventory (revised version, TCI-R)(baseline)
- Number of subject in each group with personal or familial history of addiction(baseline)