Effects of Pain Neuroscience Education on Function in Knee Osteoarthritis with Central Sensitization: A Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 124
- 试验地点
- 1
- 主要终点
- 6- minute walk test, two- point discrimination using vernier caliper
研究概览
简要总结
Osteoarthritis (OA) is the second most common chronic musculoskeletal problem. Chronic pain is a hallmark for OA knee pain, causes changes in the brain which are engaged with medial prefrontal limbic region resulting in both physical and psychological changes, the phenomenon of central sensitization plays a crucial role in subjects with chronic arthritic pain resulting from hypersensitivity of central nervous system. Current evidence provide strong support for pain neuroscience education which positively influences pain rating pain knowledge improving limitation of movement and fear avoidance behaviour .Majority of literature review suggest that both clinical identification and treatment of OA using pain neuroscience education in reducing pain intensity improving cognition,emotional and functional aspects is still insufficient.
研究设计
- 研究类型
- Interventional
- 分配方式
- Other
- 盲法
- Outcome Assessor Blinded
入排标准
- 年龄范围
- 50.00 Year(s) 至 70.00 Year(s)（—）
- 性别
- All
入选标准
- •Individuals diagnosed with OA using American College of Rheumatology (ACR) guidelines that described OA based on clinical examination as knee pain in addition to 3 of the following 6 criteria: -more than 50 years of age -less than 30 minutes of morning stiffness -crepitus -bony tenderness -no enlargement, or an absence of palpable warmth -along with radiographic classification of OA knee by Kellegren and Lawrence.
- •Knee pain for more than 3 months Symptoms of hyperalgesia measured using two-point discrimination device vernier caliper NPRS > 3 on walking.
排除标准
- •Systemic inflammatory arthritis Intra- articular corticosteriod injection within 6 months A history of hip or knee surgeries Individuals with associated neurological deficits Intention to start or currently participating in lower limb exercise programs.
结局指标
主要结局
6- minute walk test, two- point discrimination using vernier caliper
时间窗: Baseline, at the end of 8th week
次要结局
- Numerical Pain rating Scale(Baseline, at the end of 8th week)
- Central Sensitization Inventory scale(Baseline, at the end of 8th week)
- Knee Injury and Osteoarthritis Outcome Survey (KOOS)(Baseline, at the end of 8th week)
- Pain Catastrophizing Scale (PCS)(Baseline, at the end of 8th week)
- Quantitative Sensory Testing - Pain Pressure Threshold(Baseline, at the end of 8th week)