Proteins From Duckweed Trial
- Conditions
- Degree of Digestilbility
- Interventions
- Dietary Supplement: Duckweed proteinDietary Supplement: Whey protein
- Registration Number
- NCT03823222
- Lead Sponsor
- Wageningen University and Research
- Brief Summary
This study aims to study the digestibility of isolated duckweed protein. The digestibility of the isolated duckweed protein will be compared to an isolated benchmark protein whey.
Objective: The primary objective is to investigate the digestibility of isolated duckweed protein and the isolated benchmark protein whey.
Study design: The study is a cross-over, double blind, controlled trial in which study participants will visit the research facility on two occasions under fasting conditions. Subjects will receive two protein sources in randomized order with a washout period of one week. Blood will be collected via a catheter before and up-to 3 hours after protein consumption.
Study population: We aim to include 12 healthy volunteers aged 18-50 years. Intervention: Study participants will receive 20 grams of isolated duckweed protein and the isolated benchmark protein whey.
Main study parameters/endpoints: The main study parameter is blood amino acids measured before and after consumption of 20 g protein.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 12
- Body mass index (BMI) between 18 and 25 kg/m2
- Having veins suitable for blood sampling via a catheter (judged by study nurse/ medical doctor)
- Any metabolic, gastrointestinal, inflammatory or chronic disease (such as diabetes, anaemia, hepatitis, cardiovascular disease)
- History of gastro-intestinal surgery or having (serious) gastro-intestinal complaints
- History of liver dysfunction (cirrhosis, hepatitis) or liver surgery
- Kidney dysfunction (self-reported)
- Use of medication that may influence the study results, such as gastric acid inhibitors, laxatives, stomach protectors and drugs that can affect intestinal motility
- Anaemia (Hb values <7.5 for women and <8.5 for men)
- Reported slimming, medically prescribed, vegan/vegetarian or other extreme diets or the use of protein supplements
- Not willing to give up blood donation during the study
- Current smokers
- Alcohol intake ≥4 glasses of alcoholic beverages per day
- Pregnant, lactating or wishing to become pregnant in the period of the study (self-reported)
- Abuse of illicit drugs
- Food allergies for products that we use in the study
- Participation in another clinical trial at the same time
- Being an employee of the department Consumer Science & Health group of Wageningen Food & Biobased Research
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Duckweed protein Duckweed protein 20 gram of isolated protein Whey protein Whey protein 20 gram of isolated protein
- Primary Outcome Measures
Name Time Method Change in blood free amino acids (e.g. Degree of digestibility) 20 gram protein will be consumed and blood samples will be taken before and up to 3 hours after protein consumption postprandial test, determine free amino acids in blood samples collected before and after a postprandial challenge test
- Secondary Outcome Measures
Name Time Method change in plasma glucose 20 gram protein will be consumed and blood samples will be taken before and up to 3 hours after protein consumption before and after a postprandial challenge test
change in plasma insulin 20 gram protein will be consumed and blood samples will be taken before and up to 3 hours after protein consumption before and after a postprandial challenge test
Trial Locations
- Locations (1)
Stichting Wageningen Research
🇳🇱Wageningen, Gelderland, Netherlands