Fresh Corneal Lenticule Implantation and Autologous Serum - New Approach in Treatment of Advanced Keratoconus Disease - Case Report
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Keratoconus
- Sponsor
- Eye Hospital Pristina Kosovo
- Enrollment
- 1
- Locations
- 1
- Primary Endpoint
- Treatment of advanced keratoconus disease
- Status
- Active, not recruiting
- Last Updated
- last year
Overview
Brief Summary
The aim of our study is to investigate the feasibility and the effect of fresh lenticule implantation as allogenic graft that will be taken from myopic patients to implant in patients with keratoconus disease using VisuMax Femtosescond laser- Smile module surgery with primary objective to increase central corneal thickness and secondary to improve visual acuity and reduces K-values and to show the autologous serum drop improve the recovery of patients with mild dry eye in keratoconus disease.
Detailed Description
A 19-year-old female patient with keratoconus and chronic hydrops cornea referred to the cornea department of our clinic with thin cornea and hydrops in chronic stage and minimal dry eye symptoms. Minimum corneal pachymetry in the right eye was 378 µm as measured by optical coherence tomography(AS-OCT-Zeiss). Atlas corneal topography showed steep K-values 82.60 ax.37 and flat K 75.15 D ax 127 with -7.45 corneal astigmatism. Her best corrected visual acuity was 0.0.5 in right eye and 1.0 in the left eye. Slit lamp examination showed intense punctate epitheliopathy (Figure 1), tear film break-up time (TBUT) was measured as 7-8 sec and Schirmer test was 10 mm in right eye, and the other eye examinations were determined normally.
Investigators
Dr. Faruk Semiz
Head of Ophthalmology Department
Eye Hospital Pristina Kosovo
Eligibility Criteria
Inclusion Criteria
- •Be at least 18 years of age, male or female, of any race
- •Willingness and ability to follow all instructions and comply with schedule for follow-up visits
- •For females: Must not be pregnant
Exclusion Criteria
- •Contraindications, sensitivity or known allergy to the use of the test article(s) or their components
- •If female, pregnant
Outcomes
Primary Outcomes
Treatment of advanced keratoconus disease
Time Frame: 12 months
Change of corneal central thickness using fresh lenticule with stromal stem cells, live keratocites and autologous serum