ANalyzing Olfactory Dysfunction Mechanisms In COVID-19
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- SARS-CoV-2
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
- Enrollment
- 150
- Locations
- 1
- Primary Endpoint
- Prevalence of SARS-CoV-2 in the sampled tissue
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
We aim to understand the mechanism of olfactory dysfunction in COVID-19.
Detailed Description
In December 2019, a new coronavirus causing severe acute respiratory syndrome was described in Wuhan, China. This virus, later named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), spread worldwide and has been designated a pandemic by the World Health Organization. By the beginning of March 2020, several Ear, Nose, Throat societies raised awareness of a frequent association between coronavirus disease 2019 (COVID-19) and smell disorders. In the present study, the investigators wish to begin to understand the pathogenesis of olfactory dysfunction in COVID-19.
Investigators
Laura Van Gerven
Professor doctor
Universitaire Ziekenhuizen KU Leuven
Eligibility Criteria
Inclusion Criteria
- •Deceased hospitalised patients, tested positive or negative for SARS-CoV-2 for patient or control group respectively
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Prevalence of SARS-CoV-2 in the sampled tissue
Time Frame: Immediately after death
In the sampled tissues, the investigators will determine presence of SARS-CoV-2 by means of immunohistochemistry, RNA-scope and spatial transcriptomics