The Effect of Zhichan Granule on intestinal flora metabolism in patients with Parkinson's disease
- Conditions
- Parkinson's disease
- Registration Number
- ITMCTR2000004015
- Lead Sponsor
- Shanghai Hospital of Traditional Chinese Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- Not specified
(1) Those who meet the diagnostic criteria of Parkinson's disease and those with liver and kidney deficiency and Qi and blood deficiency in TCM syndrome diagnosis criteria (please refer to the plan for details);
(2) The age was 50-80 years old;
(3) Hoehn & Yahr grade was I-II;
(4) Informed consent and willing to participate in the study.
(1) There was a history of repeated brain injury and stroke, accompanied by progressive progression of Parkinson's disease;
(2) When symptoms appeared, antipsychotics and / or dopamine depletion drugs were used;
(3) CT scan showed intracranial tumor or communicating hydrocephalus;
(4) More than one relative was ill;
(5) Patients with persistent remission or rapid development;
(6) High dose levodopa is ineffective
(7) Patients with other nervous system diseases and uncontrolled other system diseases;
(8) Combined with liver, kidney, hematopoietic system and endocrine system and other serious primary diseases, mental disease and dementia patients;
(9) Drug abuse and other research drugs at the same time;
(10) The patient is in critical condition, and it is difficult to correctly evaluate the efficacy and safety of the trial drug;
(11) Other drugs affecting this study are being used.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Faeces;UPDRS;
- Secondary Outcome Measures
Name Time Method CSS;Metabolites of fecal flora;Score of TCM Syndrome Scale;