The Impact of Single-shot Adductor Canal Block Versus Continuous Femoral Nerve Block on Rehabilitation After Total Knee Replacement

Not Applicable

Recruiting

• Conditions: Osteo Arthritis Knee; Gonarthrosis
• Interventions: Procedure: Continuous femoral nerve block; Procedure: Single-shot adductor canal block

• Registration Number: NCT05487053
• Lead Sponsor: Negovsky Reanimatology Research Institute

Brief Summary

Total knee replacement (TKR) is considered the most effective and safe method of radical treatment of late stages of knee osteoarthritis. A well-known problem of TKR is a severe postoperative pain syndrome, which is observed in more than 50% of patients.

Femoral nerve block (FNB) is the "gold standard" for continuous postoperative analgesia after total knee replacement, as it is effective in reducing the frequency of use of opioid analgetics and reduce the duration of hospitalization. At the same time, the negative effect of this method is the motor blockade of the quadriceps femoris muscle which leads to functional impairment and is associated with an increased risk of falling.

Adductor canal block (ACB) provides adequate analgesia comparable to femoral nerve block. Moreover, ACB doesn't affect the motor function of the quadriceps femoris muscle.

The possibility of enhanced recovery after total knee replacement is the reason to compare single-shot adductor canal block and continuous femoral nerve block.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-08-03
• Study First Submitted QC: 2022-08-03
• Study First Posted: 2022-08-04
• Study Start: 2024-02-03
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-24
• Last Update Posted: 2025-03-27
• Primary Completion: 2027-12-01
• Study Completion: 2028-07-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 220

Inclusion Criteria

• Age ≥ 18
• Planned primary total knee replacement
• Planned neuraxial anesthesia
• Written informed consent

Exclusion Criteria

• Urgent surgery
• Planned revision total knee replacement
• Known allergic reaction to anesthetics
• Confirmed localized infection at the puncture sites
• Confirmed localized tumor at the puncture sites
• Peripheral neuropathy of the lower extremities
• Parkinson's disease
• Previously enrolled in this trial

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Continuous femoral nerve block	Continuous femoral nerve block	-
Single-shot adductor canal block	Single-shot adductor canal block	-

Primary Outcome Measures

Name	Time	Method
Ambulation distance	postoperative day 1	Less meters means worse outcome

Secondary Outcome Measures

Name	Time	Method
Timed up and go test	postoperative day 2	More seconds means worse outcome
10 meters walk test	postoperative day 2	More seconds means worse outcome
length of hospitalization	30 day	time from the day of surgery to the day of discharge
30 seconds chair stand test	postoperative day 2	Less exercise done means worse outcome
Ambulation distance	postoperative day 2	Less meters means worse outcome
5 times sit to stand test	postoperative day 2	More seconds means worse outcome
time to readiness to dicharge	30 day	time from the day of surgery to the day of readiness to discharge

Trial Locations

Locations (1)

Clinical Hospital on Yauza; 🇷🇺 Moscow, Russian Federation