B cell phenotyping in malaria patients

Not Applicable

Completed

• Conditions: Health Condition 1: null- Malaria Patients(P vivax and P falciparum) Non malaria patientsHealthy volunteers

• Registration Number: CTRI/2018/02/012087
• Lead Sponsor: Tata Institute of Fundamental Research

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 83

Inclusion Criteria

Females and males of age 5 and above and upto the age of 70 years with clinically suspected malaria on treatment with antimalarials and/or uncomplicated symptomatic malaria (proven) as indicated by the presence of blood smears positive for P falciparum or P. vivax asexual parastemia

Participants (living/working with the malaria patients) of either gender with age more than 18 and upto a maximum of 70 years

Participants of either gender with age more than 18 (upto a maximum of 70 yers) and suffering from non- malarial fever

Willing to participate in this study and ability to comply with the study protocol

Exclusion Criteria

Inability to comprehend or unwillingness to follow the study protocol.

Complicated malaria patients ( patients with cerebral malaria multiple organ dysfunction severe anemia)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Percentage of B cell subsets TLR4 expression and antiparasite antibody profiles on day 1 (main) and day 30 (preferably)Timepoint: Blood collection will be done on Day 1 and Day 30

Secondary Outcome Measures

Name	Time	Method
ILTimepoint: NI