Pilot study: probiotics in children with atopic dermatitis and food allergy - is there an in vivo or in vitro effect on the immunological response?

Completed

• Conditions: Food allergy, atopic dermatitis; Skin and Connective Tissue Diseases; Atopic dermatitis

• Registration Number: ISRCTN28834761
• Lead Sponsor: Winclove BioIndustries BV (Netherlands)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2005-12-20
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 13

Inclusion Criteria

1. 0 - 3 years of age
2. Atopic dermatitis
3. History strongly suggestive of food allergy or positive placebo-controlled food challenge
4. Immunoglobulin E Radioallergosorbent Test (IgE RAST) greater than or equal to 0.7 kU/l for at least two food allergens
5. Skin Prick Test (SPT) greater than or equal to 2+ for at least two food allergens

Exclusion Criteria

1. Other systemic diseases
2. Immunocompromised
3. Systemic treatment with immunomodulating drugs

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Allergen-specific T-cell response, B cell response.

Secondary Outcome Measures

Name	Time	Method
1. SCORing Atopic Dermatitis (SCORAD)<br>2. Immunoglobulin E Radioallergosorbent Test (IgE RAST)<br>3. Skin Prick Test (SPT)