Esmolol or Nitroglycerin Infusion for Blood Pressure Control Prior to Cardiopulmonary Bypass(CPB) in Cardiac Surgery: a Randomized, Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- Diastolic Blood Pressure Excursions Beyond Predetermined Lower Limits, Normalized Per Hour
研究概览
简要总结
This is an investigator initiated, sponsored, open label, prospective randomized controlled trial to be performed in adult patients undergoing scheduled cardiac surgery. Patients will be randomized to esmolol infusion or nitroglycerin infusion for control of hypertension that occurs during cardiac surgery from induction of anesthesia to initiation of cardiopulmonary bypass (CPB).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •adult patients scheduled for cardiac surgery at LLUMC University Hospital will be eligible for participation in this study.
排除标准
- •severe LV (left ventricle)dysfunction (EF < 35%).
- •emergency procedures.
- •procedures with combined carotid artery surgery.
- •patients at high risk for stroke.
- •hemodynamically significant dysrhythmias.
- •pre-existing atrial fibrillation or high degree AV (atrioventricular block).
- •pacemaker dependency.
- •known sensitivity to beta blockers.
- •patient refusal.
研究组 & 干预措施
Nitroglycerin
nitroglycerin titrated to control hypertension between anesthesia induction and initiation of cardiopulmonary bypass
干预措施: nitroglycerin (Drug)
Esmolol
esmolol titrated to control hypertension between anesthesia induction and initiation of cardiopulmonary bypass
干预措施: esmolol (Drug)
结局指标
主要结局
Diastolic Blood Pressure Excursions Beyond Predetermined Lower Limits, Normalized Per Hour
时间窗: Participants were followed from Anesthesia Induction to Initiation of Cardiopulmonary Bypass, an average of 5 hours
Area under the curve (AUC) of Diastolic Blood Pressure Excursions Beyond Predetermined Lower Limits, Normalized Per Hour from Anesthesia Induction to Initiation of Cardiopulmonary Bypass
次要结局
- Title: Systolic Hypertension(Participants were followed from Anesthesia Induction to Initiation of Cardiopulmonary Bypass, an average of 5 hours)
研究者
Richard Applegate
Principal Investigator
Loma Linda University