Aspirin in Asymmetrically Intrauterine Growth

Phase 2

Completed

• Conditions: Intrauterine Growth Restriction Asymmetrical
• Interventions: Drug: Aspirin

• Registration Number: NCT03038607
• Lead Sponsor: Assiut University

Brief Summary

Intrauterine growth restriction refers to a fetus that has failed to get a specific measures by a gestational age. Asymmetric type of Intrauterine growth restriction is known by normal sized head with smaller abdomen.It is important to recognize the growth restricted fetuses, because these fetuses may have fetal or neonatal complications.

When blood flow is increased, the oxygen and nutrients will deliver good to the fetus. The role of low-dose aspirin therapy in management of intrauterine growth restriction is controversial. It has been used, in many studies, in prevention of intrauterine growth restriction especially in women at high risk of pre-eclampsia or obstetrical antiphospholipid syndrome.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-01
• Status Verified: 2017-01
• Primary Completion: 2017-01
• Study Completion: 2017-01
• Study First Submitted: 2017-01-29
• Study First Submitted QC: 2017-01-29
• Last Update Submitted: 2017-01-29
• Study First Posted: 2017-01-31
• Last Update Posted: 2017-01-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 60

Inclusion Criteria

• The pregnant women
• 28-30 weeks
• Idiopathic asymmetrically intrauterine growth restriction
• Middle aged women (20-35 years)
• Women with abnormal umbilical artery Doppler flow indices ( > +2 standard deviation above mean for gestational age)

Exclusion Criteria

• Women less than 20 and more than 35 years
• hypertensive or diabetic women
• any type of smoking
• multiple pregnancies
• amniotic fluid index <5 cm
• premature pre-labor rupture of membranes
• abnormal placenta
• any fetal congenital malformations.
• women had absent diastolic flow or reversed flow in umbilical artery at the time of recruitment.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Aspirin group	Aspirin	-

Primary Outcome Measures

Name	Time	Method
Estimated fetal weight	6 weeks

Secondary Outcome Measures

Name	Time	Method
Birth weight	6 weeks
Changes in Doppler blood flow indices in umbilical artery	6 weeks

Trial Locations

Locations (1)

Women Health Hospital - Assiut university; 🇪🇬 Assiut, Egypt