Effect of Low-dose Aspirin on Fetal Weight of Idiopathic Asymmetrically Intrauterine Growth Restricted Fetuses With Abnormal Umbilical Doppler Indices
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Estimated fetal weight
研究概览
简要总结
Intrauterine growth restriction refers to a fetus that has failed to get a specific measures by a gestational age. Asymmetric type of Intrauterine growth restriction is known by normal sized head with smaller abdomen.It is important to recognize the growth restricted fetuses, because these fetuses may have fetal or neonatal complications.
When blood flow is increased, the oxygen and nutrients will deliver good to the fetus. The role of low-dose aspirin therapy in management of intrauterine growth restriction is controversial. It has been used, in many studies, in prevention of intrauterine growth restriction especially in women at high risk of pre-eclampsia or obstetrical antiphospholipid syndrome.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •The pregnant women
- •28-30 weeks
- •Idiopathic asymmetrically intrauterine growth restriction
- •Middle aged women (20-35 years)
- •Women with abnormal umbilical artery Doppler flow indices ( > +2 standard deviation above mean for gestational age)
排除标准
- •Women less than 20 and more than 35 years
- •hypertensive or diabetic women
- •any type of smoking
- •multiple pregnancies
- •amniotic fluid index <5 cm
- •premature pre-labor rupture of membranes
- •abnormal placenta
- •any fetal congenital malformations.
- •women had absent diastolic flow or reversed flow in umbilical artery at the time of recruitment.
研究组 & 干预措施
Aspirin group
干预措施: Aspirin (Drug)
结局指标
主要结局
Estimated fetal weight
时间窗: 6 weeks
次要结局
- Birth weight(6 weeks)
- Changes in Doppler blood flow indices in umbilical artery(6 weeks)